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DeCS
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Descriptor English:
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ATP Binding Cassette Transporter, Sub-Family B
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Descriptor Spanish:
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Subfamilia B de Transportador de Casetes de Unión a ATP
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Descriptor Portuguese:
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Subfamília B de Transportador de Cassetes de Ligação de ATP
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Synonyms English:
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ATP-Binding Cassette, Sub-Family B Proteins
ATP Binding Cassette Transporter, Sub Family B
ATP Binding Cassette, Sub Family B Proteins
P Glycoproteins
P-Glycoproteins
Multidrug Resistance Proteins
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Tree Number:
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D12.776.157.530.100.652
D12.776.157.530.450.074.500.500.875
D12.776.395.550.020.610
D12.776.543.550.192.610
D12.776.543.585.100.610
D12.776.543.585.450.074.500.500.875
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Definition English:
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A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP-BINDING CASSETTE, SUB-FAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUB-FAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology. |
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Indexing Annotation English:
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note entry term: ATP-BINDING CASSETTE, SUB-FAMILY B, MEMBER 1 is also available
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See Related English:
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Drug Resistance, Multiple
Genes, MDR
Multidrug Resistance-Associated Proteins
Rhodamine 123
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History Note English:
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99; use P-GLYCOPROTEIN 1995-98
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Allowable Qualifiers English:
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Record Number:
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33637
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Unique Identifier:
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D018435
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Occurrence in VHL:
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Similar:
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DeCS CID-10 LILACS
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